Liverpool's Premier League title challenge suffered another massive blow in a 1-0 defeat to Nottingham Forest as Erling Haaland returned Manchester City to winning ways with a 3-1 victory over Brighton.
Chelsea and Manchester United both missed the chance to close on the leaders as Casemiro's stoppage time header cancelled out Jorginho's 87th minute penalty in a 1-1 draw.
City's first defeat of the season to Liverpool last weekend looked to have kick-started the Reds' season, but Jurgen Klopp's depleted side slumped to a shock defeat at the City Ground.
Forest began the day bottom of the table, but their first win since August lifted Steve Cooper's men to within one point of safety.
Taiwo Awoniyi, who spent six years at Anfield without making an appearance, scored the only goal 10 minutes into the second half.
"To score against Liverpool is a day I will never forget," said Awoniyi.
Without the injured Darwin Nunez, Diogo Jota and Luis Diaz and with Thiago Alcantara missing due to illness, Liverpool lacked the guile to break Forest down from open play.
But they did have plenty of opportunities from set-pieces as Virgil van Dijk missed three big chances.
"How we cannot score from the set-pieces, I have no idea," said Klopp. "That's it pretty much. So the performance I can explain, the result not really."
Defeat leaves Liverpool still down in seventh, 11 points adrift of leaders Arsenal having played a game more.